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Abstract #0987

Native T1 is a Generic Imaging Biomarker of Response to Chemotherapy in Neuroblastoma

Yann Jamin1, Elizabeth R. Cullis2, Lynsey Vaughan2, Hannah Webber2, Jessica K. R. Boult1, Lauren C. Baker1, Dow-Mu Kow1, Louis Chesler2, Simon P. Robinson1

1CRUK & EPSRC Cancer Imaging Centre, The Institute of Cancer Research & Royal Marsden NHS Trust, Sutton, United Kingdom; 2Paediatric Oncology, The Institute of Cancer Research, Sutton, United Kingdom

In this study, we have challenged the TH-MYCN transgenic neuroblastoma murine model, which is a faithful representation of high-risk childhood neuroblastoma, with three different classes of anti-cancer agent: the conventional cytotoxic drugs cyclophosphamide (CPM) and methotrexate (MTX), the VEGF signalling inhibitor cediranib, and the tubulin-binding agent N-acetyl colchinol (ZD6126). We demonstrate a systematic reduction in T1 upon successful treatment and that the accurate quantification of T1 thus affords a generic, noninvasive and clinically translatable biomarker for chemotherapy-mediated cell death in the TH-MYCN neuroblastoma model.