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Abstract #0996

Effects of Downmodulation of Choline Kinase on MRS Choline Profile & Transcriptome in Ovarian Cancer Cells

Anna Granata1, Egidio Iorio2, Maria Teresa Comito1, Alessandro Ricci2, Maria Elena Pisanu2, Zaver M. Bhujwalla3, Franca Podo2, Silvana Canevari1, Delia Mezzanzanica1, Marina Bagnoli1

1Fondazione IRCCS Ist. Nazionale Tumori, Milano, Mi, Italy; 2Cell Biology & Neurosciences, Istituto Superiore di Sanit, Roma, RM, Italy; 3John Hopkins University, Baltimore, MA, United States

Detection and characterization by magnetic resonance spectroscopy of altered phosphatidylcholine metabolism in epithelial ovarian cancer (EOC) could provide choline-based imaging approaches as powerful tools to improve diagnosis and identify new therapeutic targets.