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Abstract #1071

Using DCE-MRI Data to Constrain & Simplify PET Kinetic Modeling

Jacob U. Fluckiger1, Xia Li1, Jennifer Whisenant1, Lei Xu1, Junzhong Xu1, Todd E. Peterson1, John C. Gore1, Thomas Yankeelov1

1Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States

Quantitative PET modeling is made difficult by the inability to separate tissue time activity curves into their constituent compartments. DCE-MRI modeling could be used in conjunction with dynamic PET imaging to overcome this limitation. The fractional volume parameters measured from a DCE-MRI scan can be used to separate tissue time activity curves and simplify PET modeling.