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Abstract #1077

Feasibility of Dual Pharmacokinetic Modeling using Gd-DTPA/MRI & 18F-FDG/PET

ric Poulin1, tienne Croteau1, Rjean Lebel1, Luc Tremblay1, Roger Lecomte1, M'Hamed Bentourkia1, Martin Lepage1

1Nuclear Medicine & Radiobiology, Universit de Sherbrooke, Sherbrooke, Quebec, Canada

The purpose of this study was to evaluate the correspondence between the AIF derived from MRI and PET, and to determine whether the AIF obtained by one modality can be converted into the AIF for the other modality. We showed that Gd-DTPA and 18F-FDG AIF were not identical but that using a bi-exponential model, we were able to convert Gd-DTPA AIF to 18F-FDG AIF, and vice versa. No statistical difference was found between area under the curve of experimental and converted curves. Results suggest that it would be possible to perform dual kinetic modeling using MRI and PET.