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Abstract #1086

Comparison of DCE-MRI & Dual Echo DSC-MRI Derived Measures of Ktrans & ve

Christopher Chad Quarles1, John Christopher Gore1, Thomas Edison Yankeelov1

1Radiology & Radiological Sciences, Vanderbilt University, Nashville, TN, United States

We have previously demonstrated that dual-echo DSC-MRI can be used to separate and quantify T1 and T2* based contrast agent leakage effects and, when combined with a pre-contrast T1 map, quantify the DCE-MRI parameters, Ktrans and ve. To further verify this approach we now compare DSC-MRI and DCE-MRI derived Ktrans and ve values in two brain tumor models with dissimilar perfusion characteristics and contrast agent dynamics. The DSC-MRI and DCE-MRI parameters were highly correlated and in good agreement as no significant differences were found in either of the tumor models.