Yann Jamin1, Jessica K. R. Boult1,
Lauren C. Baker1, Simon Walker-Samuel2, Arne stman3,
Simon P. Robinson1
1CRUK & EPSRC Cancer
Imaging Centre, The Institute of Cancer Research & Royal Marsden NHS
Trust, Sutton, United Kingdom; 2UCL Centre for Advanced Biomedical
Imaging, Department of Medicine & Institute of Child Health, University
College London, United Kingdom; 3Cancer Center Karolinska,
Karolinska Institutet, Stockholm, Sweden
Mature, more patent vasculature is predicted to have more complete endothelial lining, basal membrane and smooth muscle and hence reduced permeability. The latter has not been yet unequivocally demonstrated in vivo. We have used DCE-MRI to interrogate tumours derived from B16 melanoma cells engineered to express PDGF-BB (B16/PDGF), which have previously been shown to exhibit a significantly more mature vasculature, compared to wild-type B16 melanomas (B16/ctr). Results show that PDGF/B16 tumours present a lower IAUCG60 and T1 than B16/ctr tumours, suggesting that B16/PDGF tumours present a reduced vascular permeability compared to B16/ctr tumours.
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