Meeting Banner
Abstract #1123

Combined Implications of Bones Structural & Material Impairment Following Renal Transplantation Assessed by μMRI Based Finite-Element Modeling

Chamith S. Rajapakse1, Yusuf A. Bhagat1, Mary B. Leonard2, Jeremy F. Magland1, James H. Love1, Wenli Sun1, Felix W. Wehrli1

1University of Pennsylvania School of Medicine, Philadelphia, PA, United States; 2The Children's Hospital of Philadelphia, Philadelphia, PA, United States

Ordinarily, when generating micro-finite-element (μFE) models on the basis of High-resolution MRI (μMRI), bone tissue is assumed to have a constant modulus because μMRI-based in-vivo measures of bone mineralization are not yet available. As a consequence, μMRI-based μFE analysis is not sensitive to changes in bone-mineral density (BMD) observed in patient populations such as those who undergo renal transplantation (RTxp). Here, we demonstrate the increased sensitivity achieved when using μMRI-based μFE models of distal tibia with subject-specific tissue modulus which incorporate peripheral quantitative computed tomography (pQCT)-derived BMD measures compared to when a constant modulus is assumed in RTxp recipients.