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Abstract #1139

Direct Comparison of Parameters of Skeletal Muscle Energy Metabolism

Albrecht Ingo Schmid1,2, Vera Schrauwen-Hinderling3, Martin Andreas4,5, Michael Wolzt4, Ewald Moser1,2, Michael Roden6,7

1MR Center of Excellence, Medical University of Vienna, Wien, Austria; 2Centre of Medical Physics & Biomedical Engineering, Medical University of Vienna, Wien, Austria; 3Department of Radiology & Human Biology, Maastricht University Medical Center, Wien, Netherlands; 4Department of Clinical Pharmacology, Medical University of Vienna, Wien, Austria; 5Department of Surgery, Medical University of Vienna, Wien, Austria; 6Institute for Clinical Diabetology, German Diabetes Center, Department of Metabolic Diseases, Heinrich-Heine University, Düsseldorf, Germany; 7Karl-Landsteiner Institute of Endocrinology & Metabolism, Wien, Austria

Saturation transfer and PCr kinetics in ischemia and recovery were used to measure skeletal muscle ATP production in eight male healthy subjects. Saturation transfer rates were 0.21.04mM/s compared to Q=0.00790.0015mM/s derived from ischemia-induced PCr decrease, both measures of resting state ATP demand. Despite the large difference in absolute values, there was, however, a strong, significant correlation between saturation transfer, PCr decrease and recovery, despite the fact that PCr recovery measures mitochondrial, oxidative capacity. This interesting fact is to be considered when evaluating recent publications on skeletal muscle energy metabolism, especially those using the saturation transfer technique.