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Abstract #1143

Morphological & Metabolic Characterization of a New Model of Spinal Cord Injury Without Reloading using 1H MRI & 31P NMR Spectroscopy

Celine Baligand1, Ravneet S. Vohra2, Fan Ye2, Jonathon Keener3, Wootaek Lim2, Sean Charles Forbes2, Prithvi K. Shah2, Prodip Bose3,4, Glenn A. Walter1, Floyd Thompson3,4, Krista H. E. Vandenborne2

1Physiology & Functional Genomics, University of Florida, Gainesville, FL, United States; 2Physical Therapy, University of Florida, Gainesville, FL, United States; 3North Florida/South Georgia Veterans Health System of Florida, Gainesville, FL, United States; 4Departments of Physiological Science & Neurology, University of Florida, Gainesville, FL, United States


MRI and dynamic 31P spectroscopy were used to characterize morphology and function in a new rat model of muscle atrophy with incomplete spinal cord injury (SCI) combined to cast immobilization (IMM). We demonstrated that IMM prevented muscle recovery due to reloading, and show slower phosphocreatine recovery after exercise in SCI animals.

Keywords

spinalcordmuscleweekcastcoilimmobilizationinjury