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Abstract #1147

Probing Tissue Microstructure using Oscillating Diffusion Gradients in the Human Calf

Damien Joseph McHugh1,2, Penny L. Hubbard1,2, Sha Zhao1,2, David M. Higgins3, Geoff J. Parker1,2, Josephine H. Naish1,2

1Imaging Sciences & Biomedical Engineering, University of Manchester, Manchester, United Kingdom; 2The University of Manchester Biomedical Imaging Institute, Manchester, United Kingdom; 3Philips Healthcare, Guildford , United Kingdom

We present preliminary results of using trapezoidal oscillating gradients to reach short diffusion times and measure the apparent diffusion coefficient (ADC) in human calf muscle as a function of effective diffusion time. Oscillating gradients of various frequencies were used to look for evidence of restricted diffusion within muscle fibres, probing length scales between 6 and 14 μm. Results show a similar trend to pre-clinical studies, with ADC increasing as shorter diffusion times are reached and the barriers to diffusion are reduced. This indicates a sensitivity to microstructure and the potential for the clinical use of oscillating gradients.