Abstract #1160

Quantification of Myocellular Lipids Via 1H-MR Spectroscopy in Elderly Women: Effect of Adiposity & Physical Activity

Danchin Daniel Chen¹, Diego Hernando², Curtis Laurence Johnson¹, Armen Alex Gharibans¹, Dolores D. Guest³, Christie Ward⁴, Bhibha Das³, Ellen M. Evans⁴, John G. Georgiadis¹,⁵

¹Mechanical Science & Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States; ²Department of Radiology, University of Wisconsin, Madison, WI, United States; ³Department of Kinesiology & Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, United States; ⁴Department of Kinesiology, University of Georgia, Athens, GA, United States; ⁵Beckman Institute for Advanced Science & Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States

Single-voxel ¹H-MR spectroscopy was utilized in a cross-sectional study of elderly women (n=41) blocked on adiposity (obese vs. lean), with the lean group (n=17) further blocked on physical fitness (sedentary vs. physically active). The lipid distribution in the vastus medialis of lean/sedentary individuals was found to be similar to that of obese individuals, while lean/active individuals had a lower concentration of lipids (p<0.005) with a higher percentage stored as IMCL (p<0.1) than the obese and the lean/sedentary individuals.