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Abstract #1167

Parametric MRI for Muscle Degeneration & Regeneration

Donghoon Lee1, Shu Feng1, Daniel Chen1, Martin Kushmerick1

1University of Washington, Seattle, WA, United States

We report our efforts on MRI monitoring for the process of muscle damage and recovery over time, which was correlated with histology. Myotoxin was injected on mouse hind-limb muscle of one leg to damage the muscle and continuously monitor the processes of muscle damage and repair using multi-parametric MRI and histology. Acute damage and necrosis is evident with 1 2 days post injection, followed by macrophage infiltration then by onset of regeneration followed by recovery by the third week. Our results show parametric MRI can be a systematic monitoring tool in distinguishing underlying muscle pathology as a function of time.