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Abstract #1187

Comparison of the Region-Based & Pixel-Wise Methods for Cardiac T2* Analysis in 50 Transfusion-Dependent Thai Thalassemia Patients

Pairash Saiviroonporn1, Vip Viprakasit2, Thananya Boonyasirinant3, John C. Wood4, Rungroj Krittayaphong3

1Radiology Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 2Haematology/Oncology Division, Department of Pediatrics & Thalassemia Center, Faculty of Medicine Siriraj Hospital, Mahidol University; 3Division of Cardiology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University; 4Divisions of Cardiology, Department of Pediatrics, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, United States

The study compared the observer variability of the conventional Region-Based (RB) to the typical and proposed Pixel-Wise (PW) methods for cardiac T2* analysis in thalassemia patients. Fifty thalassemia major patients were enrolled for the study. Short axis bright- and black-blood sequences were acquired and analyzed using the RB and PW methods. Regions were defined using the whole interventricular septum (WS) or partial septum (PS). The proposed Pixel-Wise method using median of T2* values calculated from PS region provided lower intra- and inter-observer variability as compared to the conventional Region-Based or typical Pixel-Wise methods on both scanning techniques.