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Abstract #1237

MRI-Detected Intraplaque Hemorrhage in an Animal Model

Stephanie Elaine GarWai Chiu1, Alan R. Moody1,2, James Q. Zhan2, General Leung1

1Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 2Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

Intraplaque hemorrhage (IPH) detected with T1-weighted MRI has been shown to predict future ischemic events in both symptomatic and asymptomatic carotid patients. Despite the clinical relevance of IPH, there are few animal IPH models and an absence of data concerning MRI of IPH in such animal models. This study explores the suitability of a rabbit model of intraplaque-delivered red blood cells for MRI studies of in vivo IPH and presents evidence of MRI-detected IPH in this model using high resolution, T1-weighted sequences.