Abstract #1274

Monitoring Statin Therapy in Atherosclerotic Rabbits using USPIO-Enhanced MRI & FDG-PET on a New PET/MRI System

Ahmed Klink¹, Steve Davis Dickson¹, David Izquierdo¹, Jason Bini², Eric Lancelot³, Jesus Mateo⁴, Phlippe Robert⁵, Claire Corot³, Zahi A. Fayad⁶

¹Radiology, Translational and Molecular Imaging Institute, New York, NY, United States; ²Radiology, Translational & Molecular Imaging Institute, New York, 10029, United States; ³Guerbet, Paris, France; ⁴Epidemiology, Atherothrombosis & Imaging, CNIC, Madrid, Spain; ⁵Research Department, Guerbet, Paris, France; ⁶Radiology, Translational & Molecular Imaging Institute, New York, United States

Effects of statins on the inflammation/macrophage burden in atherosclerotic rabbits were monitored with PET and USPIO-enhanced MRI on combined PET/MRI system. USPIO-enhanced MRI was achieved using P904, a short circulating USPIO demonstrated to be uptaken by macrophages in the plaque while radioactive labeled glucose (FDG) was used to assess macrophage metabolic activity with PET.