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Abstract #1274

Monitoring Statin Therapy in Atherosclerotic Rabbits using USPIO-Enhanced MRI & FDG-PET on a New PET/MRI System

Ahmed Klink1, Steve Davis Dickson1, David Izquierdo1, Jason Bini2, Eric Lancelot3, Jesus Mateo4, Phlippe Robert5, Claire Corot3, Zahi A. Fayad6

1Radiology, Translational and Molecular Imaging Institute, New York, NY, United States; 2Radiology, Translational & Molecular Imaging Institute, New York, 10029, United States; 3Guerbet, Paris, France; 4Epidemiology, Atherothrombosis & Imaging, CNIC, Madrid, Spain; 5Research Department, Guerbet, Paris, France; 6Radiology, Translational & Molecular Imaging Institute, New York, United States

Effects of statins on the inflammation/macrophage burden in atherosclerotic rabbits were monitored with PET and USPIO-enhanced MRI on combined PET/MRI system. USPIO-enhanced MRI was achieved using P904, a short circulating USPIO demonstrated to be uptaken by macrophages in the plaque while radioactive labeled glucose (FDG) was used to assess macrophage metabolic activity with PET.