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Abstract #1297

In Vivo Fluorine-19 MR Angiography in a Mouse Model

Ruud B. van Heeswijk1,2, Yves Pilloud2,3, Ulrich Flgel4, Juerg Schwitter5, Matthias Stuber1,2

1Department of Radiology, Centre Hospitalier Universitaire Vaudois & University of Lausanne, Lausanne, VD, Switzerland; 2Center for Biomedical Imaging (CIBM), Lausanne, VD, Switzerland; 3Laboratory for Functional & Metabolic Imaging (LIFMET), Ecole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Switzerland; 4Institute for Cardiovascular Physiology, Heinrich Heine University, Dsseldorf, Germany; 5Center for Cardiac Magnetic Resonance & Cardiology Service, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

Fluorine-19 (19F) as part of perfluorocarbons in the blood-pool has a different frequency relative to that of protons. In theory, this can be exploited for angiography with a high contrast between the vessel lumen and the surrounding tissue. Therefore, the hypothesis was tested whether intravenously administered perfluorocarbons enables a selective and exclusive visualization of the vasculature in vivo.