Abstract #1297

In Vivo Fluorine-19 MR Angiography in a Mouse Model

Ruud B. van Heeswijk^1,2, Yves Pilloud^2,3, Ulrich Flgel⁴, Juerg Schwitter⁵, Matthias Stuber^1,2

¹Department of Radiology, Centre Hospitalier Universitaire Vaudois & University of Lausanne, Lausanne, VD, Switzerland; ²Center for Biomedical Imaging (CIBM), Lausanne, VD, Switzerland; ³Laboratory for Functional & Metabolic Imaging (LIFMET), Ecole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Switzerland; ⁴Institute for Cardiovascular Physiology, Heinrich Heine University, Dsseldorf, Germany; ⁵Center for Cardiac Magnetic Resonance & Cardiology Service, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

Fluorine-19 (¹⁹F) as part of perfluorocarbons in the blood-pool has a different frequency relative to that of protons. In theory, this can be exploited for angiography with a high contrast between the vessel lumen and the surrounding tissue. Therefore, the hypothesis was tested whether intravenously administered perfluorocarbons enables a selective and exclusive visualization of the vasculature in vivo.