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Abstract #1309

Inhibition of the Sodium-Calcium Exchanger by SEA0400 Inhibits Manganese Efflux from Isolated Hearts

Ya Chen1, Kevin Payne1, Bharath Atthe1, Akemichi Baba2, Toshio Matsuda2, Xin Yu1

1Department of Biomedical Engineering & Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, United States; 2Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan

The present study aimed at investigating whether manganese-enhanced MRI (MEMRI) is also sensitive to changes in Na+-Ca2+ exchanger (NCX) activity. Using a rapid T1-mapping method, we investigated the dynamics of R1 changes in manganese-perfused rat hearts with and without NCX inhibition by SEA0400.