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Abstract #1312

A Comprehensive Quantitative Comparison of Regional Cardiac Motion in Mice & Humans

Bernd Andr Jung1, Erica Dall'Armellina2, Stefan Neubauer2, Michael Markl1, Jurgen E. Schneider2

1Dept. of Radiology, Medical Physics, University Medical Center, Freiburg, Germany; 2Dept. of Cardiovascular Medicine, University of Oxford, United Kingdom

Tissue Phase Mapping is a well-established technique to assess regional cardiac function in humans. In mice, regional time course of the radial, rotational and longitudinal velocity components of the myocardium have not been systematically analyzed to date. The aim of our study was to perform a comprehensive quantitative analysis of myocardial wall motion in normal mice compared to velocity patterns in human hearts. Motion patterns of normal mouse hearts were similar to the human heart; however, distinct differences in regional myocardial motion were observed that might have to be considered when adapting myocardial mouse models to humans.