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Abstract #1314

MR Imaging of Hypertrophy & Cardiac Recovery in the Mouse Aorta & Heart

Bernd Jung1, Nadine Beetz2, Michael Markl1, Annette Merkle1, Lutz Hein2, Dominik von Elverfeldt1

1Dept. of Radiology Medical Physics, University Medical Center, Freiburg, Germany; 2Dept. Phamacology 2, Institute for Pharmacology, Freiburg, Germany

Cardiac loading can initiate hypertrophy. The factors identifying patients benefiting from a load removal are still not fully understood. Therefore, the mechanisms of remodeling after cardiac unloading are of high interest for therapeutic intervention. Mouse models of experimentally increased cardiac loading/unloading can provide an important tool to investigate cardiac remodeling and recovery. Small animal MRI has proven to be a useful tool for the evaluation of cardiac functional parameters. The aim of this work was to monitor changes in aortic diameter and regional cardiac function during remodeling and recovery after experimental myocardial loading by aortic stenosis using MRI and ultrasound.