Abstract #1321

Quantification of InVivo Left Ventricular Torsion & Principal Strains in Mouse Models of Hypertrophic & Dilated Cardiomyopathy

Candida Laura Desjardins¹, Yong Chen², Julian Stelzer¹, Xin Yu^2,3

¹Physiology, Case Western Reserve University, Cleveland, OH, United States; ²Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; ³Case Center for Imaging Research, University Hospitals, Cleveland, OH, United States

This study investigated the biomechanical consequences of altering the contractile properties and structural stability of cardiac myocytes. Myocardial wall strain and torsion were quantified in mouse models of hypertrophic and dilated cardiomyopathy using DENSE MRI. The amplitude and time course of strain and torsion development was severely altered in mice with complete deletion of myosin binding protein-C (cMyBP-C) or muscle LIM protein (MLP). In addition, the heterozygous cMyBP-C mice showed normal global function but decreased strain and torsion, suggesting the sensitivity of DENSE MRI in detecting subtle changes in contractility at an early stage of disease progression.