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Abstract #1325

Accelerating Global Cardiac Function Assessment in Mice using Compressed Sensing

Tobias Wech1, Angela Lemke2, Debra Medway2, Lee-Anne Stork2, Craig A. Lygate2, Stefan Neubauer2, Herbert Kstler1, Jrgen E. Schneider2

1Institute of Radiology, University of Wuerzburg, Wuerzburg, Bavaria, Germany; 2Cardiovascular Medicine, University of Oxford, Oxford, Oxon, United Kingdom

Cine-MRI is a well-established tool to assess global cardiac function in rodent models of cardiovascular disease. The aim of this study was to validate compressed sensing as an approach to accelerate cine-MRI in mice at 9.4T. Fully sampled data cine sets acquired in normal and chronically infarcted mice were 2-, 2.5-, 3- and 4-fold undersampled in post-processing and subjected to compressed sensing reconstruction. Blinded segmentation of all data showed that 3-fold acceleration is possible without impairing accuracy of left-ventricular volume and mass measurements.