Yijen Lin Wu1, Qing Ye1, Fang-Cheng Yeh1,2, Brent D. Barbe1, Lesley M. Foley1, Li Liu1, T. Kevin Hitchens1, Chien Ho1,3
1Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, PA, United States; 2Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, United States; 3Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, United States
The aim of this study to investigate the potential of integrated cardiac MRI (CMR) protocols for better assessment and diagnosis of coronary artery disease (CAD), especially for acute coronary syndrome (ACS). Our data indicate that integrated CMR with tagging and perfusion to assess myocardial perfusion and regional wall motion simultaneously might be valuable for better assessment of myocardial status after myocardial infarction, and can better assist early evaluation of ACS. In addition, we observed macrophage infiltration shortly after ischemic injury, suggesting inflammation plays a role in ischemia-reperfusion injury.