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Abstract #1336

Myocardial Blood Flow Measurement using DCE-MRI: Comparison of Region-Of-Interest & Voxelwise Analysis

Steven Sourbron1, William Morton1, David L. Buckley1, John P. Greenwood2, Sven Plein2

1Division of Medical Physics, University of Leeds, Leeds, United Kingdom; 2Division of Cardiovascular & Neuronal Remodelling, University of Leeds, Leeds, United Kingdom

Measurement of myocardial blood flow (MBF) with DCE-MRI is conventionally performed on a region-of-interest (ROI) basis. In principle a voxelwise analysis is more attractive, but the lower SNR of single-voxel curves may reduce the accuracy or precision. This study aimed to investigate in patient data (n=25) whether voxelwise MBF values are significantly different from an analysis on ROI basis. Results show that both are in very good agreement, with a systematic difference of 4%. Since a voxelwise analysis offers additional information on the heterogeneity of myocardial perfusion, these results provide a strong case for the voxelwise approach in clinical applications.