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Abstract #1358

Contrast-Enhanced Cardiac MRI of Vascular Remodeling After Myocardial Infarction using Lipid-Based Nanoparticles

Leonie E. Paulis1, Tessa Geelen1, Michael Kuhlmann2, Bram F. Coolen1, Klaas Nicolay1, Gustav J. Strijkers1

1Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 2European Institute for Molecular Imaging, University of Muenster, Muenster, Germany

In vivo monitoring of vascular remodeling after myocardial infarction can yield useful insights in the progression of global left ventricular (LV) remodeling. Extravascular contrast agents as Gd-DTPA have limited potential due to their nonspecific cardiac distribution. Therefore, the use of paramagnetic lipid-based nanoparticles was explored in acute and chronic phases of myocardial infarction with in vivo MRI and ex vivo CLSM.