Meeting Banner
Abstract #1362

Six Hours of Hyperglycemia & Hyperinsulinemia Affects Cardiac Function & Increase Myocardial Lipid Accumulation.

Martin Krssak1,2, Yvonne Winhofer3, Drazenka Jankovic3, Christian Anderwald3, Gert Reiter4, Siegfried Trattnig2,5, Anton Luger3, Michael Krebs3

1Center for Medical Physics & Biomedical Engineering, Medical University of Vienna, Wien, Austria; 2Center of Exellence, HF MR, Medical University of Vienna, Wien, Austria; 3Internal Medicine III, Medical University of Vienna, Wien, Austria; 4Siemens AG Healthcare, Wien, Austria; 5Radiology, Medical University of Vienna, Wien, Austria

To mimic the effect of postprandial diabetic hyperglycemia on the heart, myocardial lipid accumulation and myocardial function were measured by 1H MR spectroscopy and imaging in a group of young, healthy, lean subjects before and after 6h of experimentally induced hyperglycemia and associated hyperinsulinemia. This experimental protocol resulted in increase in myocardial lipid content by ~ 25% and also an increase in left ventricular ejection fraction ~4%, suggesting that these metabolic alterations might be directly responsible for myocardial steatosis in type 2 diabetes.