Abstract #1362

Six Hours of Hyperglycemia & Hyperinsulinemia Affects Cardiac Function & Increase Myocardial Lipid Accumulation.

Martin Krssak^1,2, Yvonne Winhofer³, Drazenka Jankovic³, Christian Anderwald³, Gert Reiter⁴, Siegfried Trattnig^2,5, Anton Luger³, Michael Krebs³

¹Center for Medical Physics & Biomedical Engineering, Medical University of Vienna, Wien, Austria; ²Center of Exellence, HF MR, Medical University of Vienna, Wien, Austria; ³Internal Medicine III, Medical University of Vienna, Wien, Austria; ⁴Siemens AG Healthcare, Wien, Austria; ⁵Radiology, Medical University of Vienna, Wien, Austria

To mimic the effect of postprandial diabetic hyperglycemia on the heart, myocardial lipid accumulation and myocardial function were measured by 1H MR spectroscopy and imaging in a group of young, healthy, lean subjects before and after 6h of experimentally induced hyperglycemia and associated hyperinsulinemia. This experimental protocol resulted in increase in myocardial lipid content by ~ 25% and also an increase in left ventricular ejection fraction ~4%, suggesting that these metabolic alterations might be directly responsible for myocardial steatosis in type 2 diabetes.