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Abstract #1383

Area-Specific GABA Concentration Predicts Tactile Discrimination Performance in Humans

Richard Anthony Edward Edden1, Nick Adrianus Johannus Puts2, Christopher John Evans3, David John McGonigle2,3

1Russell H Morgan Department of Radiology & Radiological Science, The Johns Hopkins University, Baltimore, MD, United States; 2School of Biosciences, Cardiff University, Cardiff, United Kingdom; 3CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom

Deficits in GABAergic transmission and perceptual processing have been implicated in a number of neuropsychiatric disorders. Here we use MEGA-PRESS MRS and tactile psychophysics to investigate the relationship between in vivo GABA concentration and individual vibrotactile thresholds in humans at 3T. GABA concentration correlated with individual vibrotactile frequency discrimination thresholds in sensorimotor cortex (R = 0.58; p < 0.02) but not in occipital cortex (n.s.). This study shows that MEGA-PRESS MRS can be used to link measures of perceptual ability to neurotransmitter concentration in the somatosensory domain.