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Abstract #1412

New Technique for Metabolite Cycled Non-Water-Suppressed Proton Spectroscopy in the Human Brain at 7T

Erin Leigh MacMillan1, Roland Kreis1, Alex Fuchs2, Maarten J. Versluis3, Chris Boesch1, Peter Boesiger2, Anke Henning2

1Dept. of Clinical Research, University of Bern, Bern, Switzerland; 2Institute for Biomedical Engineering, University & ETH Zurich, Zurich, Switzerland; 3Dept. of Radiology, Leiden University Medical Center, Leiden, Netherlands

Non-water-suppressed MRS via metabolite cycling in the mixing period of STEAM was introduced to benefit from the ability to perform corrections on individual FIDs to increase SNR, and to provide a new tool to investigate exchangeable protons. At 7T, this technique successfully reduced the gradient sideband artifacts and water baseline tail to well below the prominent upfield peaks, and showed the same information as VAPOR water-suppressed spectroscopy. Furthermore, the 7.9ppm NAA peak was much better resolved with metabolite cycled non-water-suppressed MRS at 7T when compared to previous work at 3T.