Haoyang Xing1,2, Yi Sui1, Qiyong
Gong3, Xiaohong Joe Zhou1,4
1Center for MR Research,
University of Illinois Medical Center at Chicago, Chicago, IL, United States;
2College of Physical Science & Technology, Huaxi MR Research
Center, Sichuan University, Chengdu, Sichuan, China, People's Republic of; 3Huaxi
MR Research Center, West China Hospital of Sichuan University, Chengdu,
Sichuan, China, People's Republic of; 4Departments of Radiology,
Neurosurgery & Bioengineering, University of Illinois Medical Center at
Chicago
Double-quantum coherence filtering (DQF) with PRESS localization has been used for lactate detection. The conventional techniques however suffer from spatial mismatch arising from chemical shifts. We have developed a DQF-PRESS technique using spatially and spectrally (SPSP) selective refocusing RF pulses to eliminate the spatial mismatch and improve lactate detection. This approach offered an approximately two-fold gain in signal-to-noise ratio, and successfully detected the lactate signal change in presence of excessive lipid signals in human subjects at 3T.