Abstract #1457

A New Small-Volume MR-Compatible Hollow-Fiber Bioreactor Cell Culture System

Jean-Philippe Galons^1,2, Logan Robinson³, Mike Bower⁴, Joseph Divijak⁴, Greg Russell⁵, Ted Trouard^1,4

¹Radiology, University of Arizona, Tucson, AZ, United States; ²Cancer Center, University of Arizona, Tucson, AZ, United States; ³Chemical Engineering, University of Arizona, Tucson, AZ, United States; ⁴Biomedical Engineering, University of Arizona, Tucson, AZ, United States; ⁵Physics, University of Arizona, Tucson, AZ, United States

Currently there is no commercially available perfused cell culture bioreactor system that is compatible with conventional NMR/MRI hardware. Taking advantage of new capabilities in 3D polymer printing technology we have generated a new small-volume hollow-fiber bioreactor device that is compatible with conventional vertical-bore MR magnets (top loading) and that fits within commercial 5 mm diameter RF probes. This bioreactor provides an inexpensive new tool for studying cell cultures with MR and utilizes the high sensitivity of commercial 5mm diameter RF hardware to generate high SNR.