In Situ Polarization Measurement of Hyperpolarized Solutions Prior to In Vivo 9.4T MR Experiments

Tian Cheng¹, Mor Mishkovsky^1,2, Arnaud Comment^1,2

In vivo hyperpolarized MR via dissolution DNP necessitates the transfer of the hyperpolarized solutions from the DNP polarizer to the imager prior to in vivo measurements. This process leads to unavoidable losses in polarization which are difficult to evaluate once the solution is infused into the animal. We propose a method to measure the polarization of the hyperpolarized solutions inside the imager bore at the time of the infusion. This in situ calibration allows to decouple potential problems linked to the hyperpolarization and transfer processes from in vivo acquisition issues and can lead to accurate analyses of in vivo SNR.