Jeremy Gordon1, Ian Rowland1,2,
Eric Peterson3, Sean Fain1,2
1Department of Medical
Physics, University of Wisconsin-Madison, Madison, WI, United States; 2Department
of Radiology, University of Wisconsin-Madison, Madison, WI, United States; 3Department
of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI,
United States
Gadolinium has been previously reported to increase the solid-state polarization of 1-13C pyruvate. However, gadolinium is a potent relaxation agent in the liquid state, decreasing the time available for imaging experiments for polarized nuclei. This work studies the effects of doping pyruvate solutions with lanthanides on the solid-state polarization, buildup time, and liquid-state T1. Holmium, another paramagnetic lanthanide, was found to increase the solid-state polarization at low (0.5mM) concentrations with favorable relaxation properties in the liquid state.
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