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Abstract #1514

The Influence of Bovine Serum Albumin on the T1 Relaxation of [1-13C]Pyruvate a Study at Low Fields

Benjamin M. Pullinger1, Stephen J. Kadlecek1, Nicholas N. Kuzma1, Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States

The effects of bovine serum albumin (BSA) on the T1 relaxation of DNP-hyperpolarized [1-13C]Pyruvate are studied as a function of magnetic field at varying concentrations of BSA and the DNP radical OX063 trityl. At low fields of 27.0 and 15.8 gauss the carbon-13 relaxation times are shortened by factors of 3 and 4 after addition of only 3% BSA. Our data suggests that caution should be taken in transporting hyperpolarized [1-13C]Pyruvate in the presence of albumin.