Ute Bommerich1, Thomas Trantzschel2, Joachim Bargon3, Gerd Buntkowsky4, Johannes Bernarding2
1SLNIB, Leibniz Institute for Neurobiology, Magdeburg, Germany; 2IBMI, University of Magdeburg, Magdeburg, Germany; 3Institute of Physical Chemistry, University of Bonn, Bonn; 4Eduard-Zintl-Institute for Inorganic & Physical Chemistry, Technical University Darmstadt
The generation of hyperpolarized substrates for sensitivity enhancement in MRI and MRS investigations is an emerging field. Hyperpolarization methods lead to a strong signal enhancement enabling the detection of even low concentrated substrates. As 19F nuclei do not appear in soft tissue, hyperpolarized 19F reporter molecules can provide optimal contrast for MR examinations. PHIP (ParaHydrogen Induced Polarization) is successfully applied for sensitivity enhancement but so far only a few substances are proven to exhibit 19F hyperpolarization. In this contribution we present spectra of hyperpolarized 19F nuclei detected from the first hydrogenation step to a biocompatible substrate.