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Abstract #1530

Approximating Water Exchange In Vivo in a Rat Model

Colleen Bailey1,2, Firas Moosvi1,2, Greg J. Stanisz1,2

1Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 2Medical Biophysics, University of Toronto, Toronto, ON, Canada

Intracellular-extracellular water exchange is an important marker of apoptotic cell death. In this study, the feasibility of measuring exchange in nude rats was examined. Data from three separate steady-state gadodiamide concentrations and an SPGR sequence with at four flip angles were fit to a two-pool model with exchange. The χ2 value was 55% lower than a similar model with the same number of parameters that assumed fast exchange. The exchange value in muscle, 0.24 0.10 s-1, was consistent with that found in previous studies.