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Abstract #1538

In Vivo MR Approaches to Validate the Capacity of a New Vanadium Compound as a Promising Anti-Diabetic Drug

Ana Marguerita Martins Metelo1, Rocio Prez-Carro1, Maria M. C. A. Castro2, Pilar Lpez-Larrubia1

1Instituto de Investigaciones Biomdicas "Alberto Sols", CSIC/UAM, Madrid, Spain; 2Dept. Life Sciences, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal

Diabetes mellitus is a metabolic and chronic disease that affects million people worldwide. As far as we know, it does not exist an available commercial drug to treat efficiently diabetic people. In this work we report for the first time, the use of Magnetic Resonance Imaging and Spectroscopy to show the role of VO(dmpp)2 on lipid metabolism of pre-diabetic rats. Images and 1H spectra acquired in the rat livers during treatment, showed a reversion of pathological conditions. This study not only proves the anti-diabetic capacities of VO(dmpp)2, but it also establishes MRI/MRS approaches as useful techniques in drugs development.