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Abstract #1549

Thalamic & Cortical Substrates of Large-Scale Neuronal Oscillations Assessed with Simultaneous EEG-fMRI

Zhongming Liu1, Jacco A. de Zwart1, Peter van Gelderen1, Li-Wei Kuo1, Jeff H. Duyn1

1Advanced MRI section, Laboratory of Functional & Molecular Imaging, NINDS, National Institutes of Health, Bethesda, MD, United States

Synchronized neuronal oscillations govern the dynamic behavior of neuronal networks. At rest, we used EEG to detect large-scale neuronal oscillations, whose spontaneous fluctuations were correlated with BOLD to reveal underlying sub-cortical and cortical substrates. Between BOLD and posterior alpha and central mu rhythms, we found positive correlations in anterior thalamus and negative correlations in visual and sensorimotor cortical areas. Positive BOLD-BOLD correlations to visual cortex were found at the same cortical regions. Results suggest that thalamus plays a central role orchestrating cortical oscillations within- or cross-modality, and that intrinsic functional connectivity reflects in part the interplay between cortex and thalamus.