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Abstract #1551

Neuroelectrical Basis of the Resting-State BOLD Global Signal as Determined with Simultaneous EEG-fMRI

Chi Wah Wong1, Valur Olafsson1, Omer Tal1, Anna Leigh Rack-Gomer1, Thomas T. Liu1

1Center for Functional MRI, University of California San Diego, La Jolla, CA, United States

Recent work in monkeys suggests that the BOLD global signal typically removed as a nuisance term in resting-state studies may have a neural origin. In this study we used simultaneous EEG-fMRI in humans to show that the global signal has a significant component of neuroelectrical origin. In addition, we show that the detection of the anti-correlated relation between the default mode network and the task positive network seems to depend on the removal of this neuroelectrical global signal component.