Neuroelectrical Basis of the Resting-State BOLD Global Signal as Determined with Simultaneous EEG-fMRI

Chi Wah Wong¹, Valur Olafsson¹, Omer Tal¹, Anna Leigh Rack-Gomer¹, Thomas T. Liu¹

Recent work in monkeys suggests that the BOLD global signal typically removed as a nuisance term in resting-state studies may have a neural origin. In this study we used simultaneous EEG-fMRI in humans to show that the global signal has a significant component of neuroelectrical origin. In addition, we show that the detection of the anti-correlated relation between the default mode network and the task positive network seems to depend on the removal of this neuroelectrical global signal component.