David A. Ravaee1, Claudia Huerta1, Hsiao-Ying Wey1, Ai-Ling Lin1, Timothy Duong1
This study investigated the relation between perfusion pressure and cerebral blood flow (CBF) in the human brain using MRI during rest and isometric handgrip exercise. Basal CBF was 37 4 mL/100mL/min (N=4). Isometric exercise increased mean CBF, heart rate and mean arterial pressure (P<0.05), but not O2 saturation, end tidal CO2, or respiratory rate (P>0.1). A MRI approach provides objective quantitative CBF with a large field of view without depth limitation. fMRI during isometric exercise provides a unique means to study brain physiology and autoregulation free of potential adverse pharmacological effects.