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Abstract #1590

Functional Magnetic Resonance Spectroscopy of the Rat Barrel Cortex

Nathalie Just1, Rolf Gruetter1

1LIFMET, CIBM/EPFL, Lausanne, Switzerland

In the past, Trigeminal nerve electrical stimulation was shown to be a robust model for the investigation of the BOLD fMRI changes in the rat barrel cortex. In the present study, reproducible BOLD fMRI changes were obtained during sustained 10-minute trigeminal nerve stimulation. Current observations suggest that sustained neuronal activation of the rat barrel cortex permits the investigation of the neurochemical consequences of cortical activation.