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Abstract #1619

One-Step Thresholding for BOLD Signal Detection in Accelerated fMRI

Samir D. Sharma1, Bosco S. Tjan2, Krishna S. Nayak1

1Electrical Engineering, University of Southern California, Los Angeles, CA, United States; 2Psychology, University of Southern California, Los Angeles, CA, United States

Functional magnetic resonance imaging (fMRI) with blood-oxygenation-level-dependent (BOLD) signal is fundamentally limited by the time required to acquire each volume. Standard EPI sequences with statistically advantageous TRs of 1-2s are typically restricted to acquiring no more than 16-32 slices with a typical 3 mm3 isotropic resolution. This covers only about 40-80% of the cerebral cortex. A fast imaging technique is needed for full volumetric coverage at short TRs. This work proposes a simple and fast one-step thresholding (OST) algorithm for the detection of BOLD signal activation. Results from the proposed method at 2x-acceleration demonstrate close agreement with the fully-sampled reference.