An Vo1, Aziz M. Ulug1,2,
1The Feinstein Institute
for Medical Research, Manhasset, NY, United States; 2Department of
Radiology, Albert Einstein School of Medicine, Bronx, NY, United States; 3National
Jewish Health, Denver, CO, United States; 4University of Colorado
Medical Center, Denver, CO, United States; 5Hospital for Special
Surgery, New York, United States; 6Weill Medical College of
Cornell University, New York, United States
Most patients with systemic lupus erythematosus (SLE) have cognitive dysfunction suggesting but clinically important central nervous system involvement. Antiphospholipid syndrome is another autoimmune disorder defined as the presence of arterial or venous thromboses and/or pregnancy morbidity with persistent antiphospholipid antibodies (APL). Diffusion tensor imaging (DTI) and fMRI has been used to study the SLE and APL patients. The purpose of this study is to use both fMRI and DTI features to automatically classify SLEs, APLs and normal controls.