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Abstract #1640

Field Shift Due to Paramagnetic Effect of Molecular Oxygen

Kejia Cai1, Kalli Grasley1, Anup Singh1, David Pilkinton1, Mohammad Haris1, Hari Hariharan1, Mark Elliott1, Ravinder Reddy1

1CMROI, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Oxygen inhalation has been shown to be a simple and effective positive contrast agent in T2*-weighted images based on the BOLD effect. While paramagnetic effect of molecular oxygen could shift the static field, which is unrelated to blood oxygenation. In this study, we have characterized the static field shift due to oxygen inhalation at 9.4T by using SVS and B0 field maps. Proton Larmor frequency is shifted by ~1Hz per 1% of oxygen at 9.4T. One must be cautious on this confounding factor when conducting fMRI and field sensitive MRI studies with oxygen inhalation.