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Abstract #1649

Dynamics of Cerebral Lactate During Acute Hypoxia

Ashley D. Harris1, Richard A. E. Edden2,3, Kevin Murphy1, C. John Evans1, Victoria Roberton1, Danielle Huckle4, Judith E. Hall4, Neeraj Saxena4, Damian M. Bailey5, Richard G. Wise1

1CUBRIC - School of Psychology, Cardiff University, Cardiff, United Kingdom; 2Russell H Morgan Department of Radiology & Radiological Science, The Johns Hopkins University, Baltimore, MD, United States; 3FM Kirby Research Centre for Functional MRI, Kennedy Krieger Institute, Baltimore, MD, United States; 4Department of Anaethetics, Cardiff University, Cardiff, United Kingdom; 5Department of Health, Sport & Science, University of Glamorgan, Pontypridd, United Kingdom

The role of cerebral lactate is unclear, as there is emerging evidence that it is a neural energy source, not just a by-product of anaerobic metabolism. There are also questions about cerebral metabolism during hypoxia, with some groups showing a non-intuitive result of increased cerebral metabolism during hypoxia. Here, the dynamics of lactate during an acute exposure to hypoxia and then return to normoxia are examined in 3 healthy humans with multiple repeat sessions. We show the dynamics and complexities of lactate accumulation.