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Abstract #1651

Brain Tumor Angiogenesis can be Imaged by 19F MRI: High Sensitivity Detection of Targeted PFOB Emulsion in U87 Human Glioblastoma Mouse Model

Cline Giraudeau1, Franoise Geffroy1, Aline Perrin1, Boucif Djema1, Benot Thz2, Philippe Robert3, Marc Port3, Caroline Robic3, Denis Le Bihan1, Franck Lethimonnier1, Julien Valette1

1NeuroSpin, Commissariat l'Energie Atomique, Gif sur Yvette, France; 2SHFJ, Commissariat l'Energie Atomique, Orsay, France; 3Guerbet, Research Division, Roissy Charles de Gaulle, France

19F MRI has the unique property to specifically detect administered 19F-containing compounds without background signal and thus could be a substitute to PET imaging. Using a PFOB-dedicated, high sensitivity multi spin echo sequence, we show that 19F MRI is able to reveal brain tumors after injection of an RGD-functionalized PFOB emulsion targeting v3 integrins. Our results are corroborated by fluorescence microscopy. This work demonstrates that 19F MRI may be an alternative to existing techniques to detect brain tumor angiogenesis.