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Abstract #1669

Nano-Size MR Probe Detects T Cells Infiltration in Bone Marrow & Growth Plate in Rat Model of Rheumatoid Arthritis

Chih-Lung Chen1, Cheng-Hung Chou2, Ming-Huang Lin2, Wen-Yuan Hsieh1, Hsin-Hsin Shen1, Shian-Jy Wang1, C. Chang2

1Industrial Technology Research Institute, Hsinchu, 310, Taiwan; 2Academic Sinica, Taiwan

The activation of T-cells correlates with the pathogenesis of rheumatoid arthritis (RA). Understanding the genesis, migration, and distribution of the T-cells provides important perspectives regarding RA. To monitor T-cells noninvasively and repeatedly, an in vivo labeling technique using a new nanoparticle contrast agent, IOPC, was employed. The IOPC had a longer blood circulation time that allowed uptake by cells over a longer duration. Noticeable IOPC-induced hypointensities was observed in the growth plate of the RA rat one day following in vivo IOPC labeling. Double immunohistology against IOPC and CD3 confirmed the presence of T-cells in the growth plate in RA.