Eliana Gianolio1, Luca Maciocco2,
Daniela Imperio3, Giovanni Battista Giovenzana3,
Federica Simonelli4, Kamel Abbas4, Gianni Bisi5,
Silvio Aime1
1Dept. Chemistry IFM &
Molecular Imaging Center, University of Torino, Torino, Italy, Italy; 2Advanced
Accelerator Applications (AAA), St. Genis Pouilly, France; 3DiSCAFF,
University of Eastern Piedmont A.
Avogadro", Novara, Italy; 4European Commission Cyclotron,
Institute for Health and Consumer Protection Joint Research Centre, Ispra
(VA), Italy; 5, Nucl Med Serv, Azienda Osped San Giovanni
Battista, Dipartimento Med Interna, University of Torino, Torino, Italy
In vitro study of a dual MRI/SPECT pH-responsive agent where the SPECT-active moiety (based on a Ho(III) containing complex) acts as a reporter of the concentration of the MRI active one (based on a Gd(III) containing complex) thus allowing the transformation of the observed 1H-relaxation rates into relaxivities to recover the information relative to the pH determination.