Meeting Banner
Abstract #1679

Mechanical Release from Paramagnetic Liposomes Triggered by Low Frequency Ultrasound

Enzo Terreno1, Pierangela Giustetto1, Daniela Delli Castelli1, Cinzia Boffa1, Davide Durando1, Silvio Aime1

1Molecular & Preclinical Imaging Center, University of Torino, Torino, Italy

The mechanical (i.e. non-thermic) release of the liposomal content (MRI agent and/or drug) by using pulsed low-frequency low-intense ultrasound is strongly affected by small changes in the bilayer composition, payload of imaging probe (or drug), size and shape of the nanovesicles. This finding offers the opportunity to selectively trigger the release of imaging reporters, as well as drugs, from a mixture of different nanocarriers, thus opening new therapeutic schemes to improve the overall efficacy of a pharmacological treatment.