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Abstract #1697

Magnetoliposomes Open Up New Horizons as MRI Contrast Agents.

Stefaan Soenen J. H. Soenen1, Michel Hodenius1, Marcel De Cuyper1, Uwe Himmelreich2

1Lab of BioNanoColloids, IRC, Katholieke Universiteit Leuven Campus Kortrijk, Kortrijk, Belgium; 2Biomedical NMR Unit/ MoSAIC, Katholieke Universiteit Leuven, Leuven, Flandern, Belgium

Magnetoliposomes (ML) have been developped and studied) for stable, non-toxic, longitudinal cell labelling and monitoring. In contrast to other iron oxide based nanoparticles, MLs are stable intracellularly for a long time, don't cause adverse effects on cell biology and result in stronger T2* contrast. The later is due to gradual, intracellular degredation of the outer lipid layer and subsequent clustering of the monolayer-coated iron oxide particles.