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Abstract #1703

High Sensitivity 19F MRI Allows Dynamic Biodistribution Study & Oxygen Tension Mapping at Pharmaceutical Doses of a PFOB Emulsion in the Mouse Reticuloendothelial System

Cline Giraudeau1, Boucif Djema1, Sidi Mohamed Ould Ahmed Ghaly1, Philippe Robert2, Marc Port2, Caroline Robic2, Denis Le Bihan1, Franck Lethimonnier1, Julien Valette1

1NeuroSpin, Commissariat l'Energie Atomique, Gif sur Yvette, France; 2Guerbet, Research Division, Roissy Charles de Gaulle, France

PFOB emulsions are promising tracers for quantitative 19F MRI of the reticuloendothelial system (RES). Using a PFOB-dedicated multi spin echo (MSE) sequence, we show that kinetics of accumulation of PFOB nanoparticles in the RES can be quantified and that stealth of emulsions including different quantities of polyethylene glycol can be assessed. Moreover, oxygen pressure mapping can be performed in the RES after one single injection of emulsion. These results are promising for monitoring of the RES status in vivo.