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Abstract #1712

Non-Invasive Evaluation of Chronic Cardiac Rejection After Heart Transplantation with Multi-Parameter Cellular & Functional MRI

Qing Ye1, Yijen L. Wu1, Lesley M. Foley1, Brent D. Barbe1, Fang-Cheng Yeh1, T. Kevin Hitchens1, Li Liu1, Chien Ho1

1Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, PA, United States

Cardiac allograft chronic rejection (CR) remains a major obstacle for long-term graft survival after heart transplantation. Non-invasive assessment of cardiac allograft status is highly desirable. We are developing non-invasive means for detecting allograft rejection using cardiac MRI techniques. In this study, we used a heterotopic rat model of CR to investigate longitudinal characteristics of CR progression over time with multi-parameter cellular and functional MRI. Our preliminary results indicate that simultaneous cellular and tagging MRI can evaluate rejection status non-invasively over time, which may be a reliable alternative for assessment of CR and potentially translate to clinical arena.